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Mental Health Information Centre - Southern Africa

Obsessive-compulsive and hair-pulling disorder (trichotillomania)

This is an important clinical, genetics and brain-imaging study conducted by the MRC Unit on Anxiety & Stress Disorders at Stellenbosch University in conjunction with researchers at Cambridge University in the UK. The study covers clinical aspects of these disorders – symptoms, illness severity, impact on the quality of your life, treatment history and childhood trauma history, while also looking at genetics and the structure of certain brain regions implicated in these conditions.

What is obsessive-compulsive disorder (OCD)?

In DSM-IV (which is one of the major diagnostic tools used in practice), OCD was categorised as one of the anxiety disorders. In DSM-5 however, OCD now falls under a grouping of obsessive-compulsive and related disorders. OCD is a psychiatric disorder characterised by obsessions and/or compulsions. Obsessions are persistent, “self-generated” (i.e. not delusional or psychotic) thoughts or mental images that are time-consuming, cause significant distress or functional impairment. Compulsions, on the other hand, are repetitive mental (e.g. counting, repeating words) or behavioural (e.g. hand-washing, checking) acts that the person feels obliged to perform in an attempt to reduce the anxiety or distress or preventing some dreaded event. However, compulsions are not inherently enjoyable, are often extremely time-consuming and do not result in the completion of a useful task.

What is hair-pulling disorder (HPD)?

HPD is also now categorized as an obsessive-compulsive related disorder. It is characterized by recurrent pulling out of one’s hair resulting in hair loss, with repeated attempts to decrease or stop hair pulling.The hair pulling causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

How prevalent are these disorders in SA?

OCD, together with other mental disorders like HPD, account for the 2nd largest portion on our national burden of disease after HIV/AIDS. The causality or “working” of these conditions is not yet fully established. It can therefore be argued that it is necessary to do research on disorders such as OCD and HPD, so that the symptomatology and the neurobiological underpinnings can be better understood and that improved treatments can be found.

Who can volunteer?

– Volunteers who are right-handed and aged between 18 and 65 years
– Persons with OCD or HPD
– First-degree relatives of persons diagnosed with OCD
– Healthy controls

How will it work?

Participation involves attendance of 2 sessions, with the first session comprising of a screening interview, filling out of self-report questionnaires and taking a blood sample for genetic analysis. If suitable for brain imaging, participants are scanned during a subsequent session. Participants also complete a number of neuropsychological tasks in the form of computerised games. Participation is cost-free and participant information will be kept confidential.

Who to contact to take part?

If you want more information or want to participate, please contact: Prof Christine Lochner 021 – 938 9179, e-mail: cl2@sun.ac.za or Mr Lian Taljaard 021 – 938 9654, e-mail: liant@sun.ac.za for more information.



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In partnership with:

University of Stellenbosch
South African Medical Research Council
University of Cape Town
International Brain Research Organization